Pharmacy Lok Sewa Aayog Exam Paper Solved

Pharmacy Lok Sewa Aayog Exam Paper Solved


Public Service Commission
Nepal Health Services, Pharmacy Group’s seventh level open and internal competitive examination syllabus

Section A- 20 Marks

1. Development of Pharmacy and Drug Legislation in Nepal.

1.1. Pharmaceutical development in Nepal.
1.2. The pharmaceutical institution in Nepal.
1.3. Drug legislation in Nepal.
1.4. National Health Policy, National Drug Policy, and their relation.
1.5. Role and Responsibility of Nepal Pharmacy Council

4. Pharmaceutical analysis

4.1 Fundamental titrimetric analysis: Acid-base, Oxidation-reduction, Non- aqueous, Complexometric and potentiometric titrations; Ion-selective electrodes.
4.2 Spectroscopic methods of analysis, Absorption, Visible, IR, UV spectroscopy, Fluorimetry, Polarimetry, Atomic absorption, and Emission spectroscopy.
4.3 Gravimetric analytical methods and their applications.
4.4 Separation techniques: Column, Paper, Thin layer, Ion exchange, Gel and Gas chromatography; High-Performance Liquid Chromatography, High-Performance Thin Layer Chromatography, Electrophoreses.
4.5 Extraction procedures and role of partition coefficient.
4.6 Principles and application of microbiological assay of antibiotics and vitamins.
4.7 Good Laboratory Practices, validation, reference standards.
4.8 Statistical analysis, sampling technique, analysis of variance.

Section B- 20 Marks

2. Pharmaceutics

2.1. Prescription, proper handling of prescription, incompatibilities.
2.2. Pharmaceutical dosage form: Fast, Immediate, Sustained/controlled release including novel drug delivery system. e.g. mucosal drug delivery systems.
2.3. Manufacturing; Elements of Good Manufacturing Practice; WHO Certification Scheme on the Quality of Pharmaceutical Products Moving in International Commerce and its usefulness for quality assurance; packaging and stability of pharmaceutical products, costing of pharmaceutical formulation and prediction of the maximum retail price.
2.4. Pharmaceutical additives.
2.5. Layout a plan of pharmaceutical manufacturing plant including quality control, good manufacturing practice and safety measures in factories.
2.6. Physical pharmacy; application of thermodynamics; rate and order of reaction; accelerated stability testing and shelf-life of drugs; pH; buffered and isotonic solution; solution of electrolytes; micropolitics; colloidal system; theology.
2.7. Bioavailability and Bioequivalence studies.

6. Microbiology

Scope of microbiology with special reference to pharmaceutical sciences, basic principles of sterility and pyrogen testing, fundamentals of Immunology, Testing of vaccines used in Extended Programme of Immunization. Microbial contamination test in pharmaceuticals, food, water, and environment; classification of pathogenic microorganisms. Basic principles of Biotechnology. The methodology of sterilization.


Public Service Commission
Nepal Health Services, Pharmacy Group’s seventh level open and internal competitive examination syllabus

Section C- 30 Marks

3. Pharmacognosy

3.1 Medicinal herbs of Nepal: Origin, distribution, cultivation, drying, pulverization, storage, and quality control.
3.2 Plant analysis, types of plant constituents and Physico-chemical standards.
3.3 Plant-based drugs in modern medicine.
3.4 Extraction process and isolation of active ingredients, pilot plant processing.

5. Pharmacology

5.1 Mechanism and action of drugs, their safety, uses and mode of administration.
5.2 Pharmacokinetics, pharmacodynamics and pharmacological evaluation of drugs.
5.3 Poisoning: control and treatment.
5.4 Adverse drug reaction and drug interactions.

7. Medicinal Chemistry

Characterization of organic compounds of the pharmaceutical interest and specific reactions. Synthesis of important pharmaceuticals, their pharmacological action, and antimicrobial activities.

Section D- 30 Marks

8. Drug Act & Pharmacopoeia

8.1 Legislation
8.2 Pharmacopoeia: Pharmacopoeial standards and their needs; importance and application of pharmacopoeial specification.

9. Pharmaceutical Care & Drug Supply Management

Comprehensive knowledge of clinical and hospital pharmacy: patient counseling and dosage adjustment in elderly, impaired liver and kidney; use of the drug in neonates, children, pregnancy, and lactation.
Logistics management (selection, procurement, storage, and distribution). Drug Financing Schemes (cost recovery, sharing, and insurance).
Concept of Essential Drugs, National Formulary, Hospital Formulary, and Drug & Therapeutics Committee. Standard Treatment Schedules and rational use of drugs.
Role of Pharmacist in hospital and community.


Public Service Commission
Nepal Health Services, Pharmacy Group’s seventh level open and internal competitive examination syllabus

(Sample questions)

1. Phenobarbitone induces the metabolism of
(A) Cumarine (B) Paracetamol (C) Oral contraceptives (D) Ibuprofen
Correct Answer:- (C)

2. Validation of a QC procedure is a part of :
(A) Quality system (B) GLP (C) GMP (D) QA activity
Correct Answer:- (C)

3. A pharmaceutical company received an order for a coated ranitidine tablet from the marketing department with an instruction that coated tablets should retain the company logo. Which of the following coating process would you prefer?
(A) Sugarcoating (B) Film coating (C) Enteric sugar coating (D) B and C
Correct Answer:- (B)

4. As per the USP requirement, tablets weighing more than 324 mg should not deviate by more than 5% of the average weight. Normally 20 tablets are sampled. How many tablets does USP allow to differ (this deviation should not exceed twice the limit) from the average weight?
(A) 1 (B) 2 (C) 3 (D) 4
Correct Answer:- (B)

5. The pH partition hypothesis related to drug absorption is based on the following assumption (A) Existence of stationary compartment between GIT and blood.
(B) Unionized form of the drug is more lipid-soluble.
(C) Passive diffusion of drug through the barrier.
(D) All of the above.
Correct Answer:- (D)

6. Morphine upon methylation gives
(A) Codeine (B) Nicotine (C) Heroin (D) Thebaine
Correct Answer:- (C)

(Sample questions)

1. Compare and contrast the Health and Drug policies of Nepal in relation to catering better health care services to the general public. (10 marks)
2. Describe the concept of essential drugs and national formulary. Discuss the role of the pharmacist in the community and therapeutic management of the patient. (5+5 marks)
3. Write notes on the following: (5+5 marks) a) HPLC b) Mass Spectroscopy
4. Outline the main difference between the USP and BP/EP sterility tests. (10 marks)
5. Describe principles of technological possibilities for the manufacture of oral extended-release dosage forms. Indicate where appropriate, the kinetics of release. (10 marks).

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